Translationsforschung in Gesundheitswesen und Public Health
Leitung: | Prof. Dr. Angela Brand PD Dr. Bodo Lange | |
Institut: | Maastricht University, Max-Planck-Institut für Molekulare Genetik | |
Homepage: | www.unimaas.nl |
Brain Tumor Network | Prof. Peter Lichter | Deutsches Krebsforschungszentrum Heidelberg |
Cellular Systems Genomics in Health and Disease | PD Dr. Stefan Wiemann | Deutsches Krebsforschungszentrum Heidelberg |
Deciphering Oncogene Dependencies | Dr. Roman Thomas | MPI für neurologische Forschung Köln |
Epilepsy and Migraine Integrated Network (EMINet) | Prof. Christian Kubisch | Universität Köln |
From Disease Genes to Protein Pathways (DiGTOP) | Prof. Wolfgang Wurst | Helmholtz Zentrum München |
Functional and Translational Genomics of Acute Leukemias | Prof. Christian Hagemeier | Charité Berlin |
Functional Genomics of Parkinson | Prof. Thomas Gasser | Universität Tübingen |
Gene Identification and Functional Analyses in Alzheimer´s Disease | PD Dr. Matthias Riemenschneider | Technische Universität München |
Genetics of Alcohol Addiction | Prof. Rainer Spanagel | Zentralinstitut für Seelische Erkrankungen |
Genetics of Heart Failure | Prof. Hugo Katus | Universität Heidelberg |
Genome Research Network in Pancreatic Cancer | Prof. Thomas M. Gress | Universität Marburg |
Genomics of Atherosclerosis | Prof. Heribert Schunkert | Universität Lübeck |
German Mental Retardation Network (MRNET) | Prof. André Reis | Universität Erlangen |
German Mouse Clinic - Deciphering | Prof. Martin Hrabé de Angelis | Helmholtz Zentrum München |
Integrated Genome Network of Prostate Cancer | PD Dr. Holger Sültmann | Deutsches Krebsforschungszentrum Heidelberg |
Integrated Genomic Investigation of Colorectal Carcinoma | Prof. Kari Hemminki | Deutsches Krebsforschungszentrum Heidelberg |
MHC Haplotype Sequencing: An Intergrated Approach to Common Disease | Dr. Margret Hoehe | MPI für molekulare Genetik Berlin |
List of Innovation Alliances in NGFN-Transfer
Integrated Genome Research Network |
Coordination |
Institution |
Anti-malarial Agents | Dr. Birte Sönnichsen | Cenix Bioscience Dresden |
Breast Cancer Kit | Prof. Jan G. Hengstler | Leibniz Institut für Arbeitsphysiologie an der Universität Dortmund |
Heart Failure Therapy | Prof. Markus Hecker | Universität Heidelberg |
Metabolomic signatures of heart failure | Prof. Hugo Katus | Universität Heidelberg |
New Tools for the Prevention of Cardiovascular Diseases and Disorders in Chronic Kidney Disease | PD Dr. Joachim Jankowski | Charité Berlin |
Protein analysis of formalin-fixed tumor (FFPE) samples | PD Dr. Karl-Friedrich Becker | Technische Universität München |
Subgenome Fractionation for High Throughput Sequencing | Dr. Bernhard Korn | Deutsches Krebsforschungszentrum Heidelberg |
Whole genome and transcriptome amplification in large biobanks | Prof. H.-Erich Wichmann; Dr. Christian Korfhage |
Helmholtz Zentrum München; Qiagen GmbH Hilden |
The output of the NGFN from 2001 until 2008
includes over 80 patent applications, 2,400 scientific publications, and cooperation in 60 EU projects. The gain in insight into cause and process of disease development through the identification of molecular target structures has lead to a direct transfer of the results into development and optimization of diagnostics and therapeutics. A portfolio of results is ready for in-licensing or collaboration partnerships for further development. The scientists succeeded in discovering genetic variations with implications for Alzheimer's disease, epilepsy, Depression, Parkinson´s disease, cancer, susceptibility to allergies, adipositas, coronary heart disease, heart failure and enteritis. They developed DNA chips and identified gene signatures for neuroblastoma, Parkinson's disease, prostate cancer and heart failure that constitute a substantial advance in prognosis and diagnosis. They developed tools against autoimmune diseases, established systematic proof-of-principle approaches such as animal models and cell-based assays, used active semiconductor chips to develop highly complex peptide arrays and optimized micro-endoscopes for brain analysis. In one of the world's largest projects for the analysis of disease-causing genetic variations, the genetic information of up to 25,000 patients and controls is being examined with the help of DNA chips.